In the last years, IGF-I treatment is being either tested in or proposed for a wide range of pathological circumstances, as Laron syndrome, chronic liver disease, intrauterine growth restriction, insulin resistance and diabetes, neurological disorders (Alzheimer’s disease and amyotrophic lateral sclerosis) and stroke, cystic fibrosis, wound healing, burns, etc. [36-48]. The gene discussed is IGF1; the disease is Laron syndrome.