Among them, CXCL1[26], EDN1 [27], EPAS1[28,29], GDP15[30,31], IL8[32,33], KRT17[34,35], CRKL[36,37], DTL[38], PTGFR[39], KDM3A[40], PODXL[41], RGS20[42], and TSLP[43] are observed to be frequently overexpressed in cancer cells and are suggested to be involved in cancer development, tumor progression or poorer prognostic outcome. This evidence concerns the gene EDN1 and neoplasm.