In contrast, SOD2[44,45], RHOB[46,47], G0S2[48], EMP1[49], TNFRSF4[50], TNFSF4[51], DMBT1[52,53], LIFR[54], TFPI2[55], and EPHB6[56] are frequently down-regulated in cancer and may be associated with tumor suppression or favorable prognostic outcome. The gene discussed is EPHB6; the disease is cancer.