Among them, CXCL1[26], EDN1 [27], EPAS1[28,29], GDP15[30,31], IL8[32,33], KRT17[34,35], CRKL[36,37], DTL[38], PTGFR[39], KDM3A[40], PODXL[41], RGS20[42], and TSLP[43] are observed to be frequently overexpressed in cancer cells and are suggested to be involved in cancer development, tumor progression or poorer prognostic outcome. The gene discussed is RGS20; the disease is cancer.