In the present study, we examined the possible relationship between TGase-4, a prostate specific transglutaminase-4, and cell-matrix adhesion of prostate cancer cells and have shown an important biological link between TGase-4 and the focal adhesion complex (FAC), namely FAK and paxillin in prostate cancer cells and prostate tissues. The gene discussed is PTK2; the disease is Familial prostate cancer.