C3 and kidney disorder: Occasionally, the EM appearance of C3GN closely resembles that previously described as a subtype of MPGN type 3 by Strife et al.22In CFHR5 nephropathy, histologic appearances (Fig. 2E and F) include mesangial and/or capillary wall C3 deposits on IF; a normal or mesangioproliferative pattern on LM; and mesangial, subendothelial, and occasional subepithelial deposits of only moderate density on EM.