In a number of cases in which there has been persistent renal disease after diagnosis of postinfectious GN, AP abnormalities have been detected and subsequent biopsy specimens were consistent with C3 glomerulopathy.12, 13, 14, 15 This includes a report of a young girl with acute post-streptococcal GN and low serum C3 levels in whom recurrent macroscopic hematuria prompted biopsy examinations 9 and 20 months after the initial presentation.12 The gene discussed is C3; the disease is complement 3 glomerulopathy.