Many of yHCC-enriched genes, such as CTNND2 (delta 2 catenin), RAB34 (a member of the RAS oncogene family), SOX13 (SRY (sex determining region Y)-box 13), ETV4 (ets variant gene 4), DNMT1 (DNA cytosine-5-methyltransferase 1), TLE3 (transducin-like enhancer of split 3), MLL (myeloid/lymphoid or mixed-lineage leukemia), and MLL2, have been associated with tumor malignancy and poor patient outcomes in HCC or other cancers (Figure 1E, underlined). Here, TLE3 is linked to cancer.