Many of yHCC-enriched genes, such as CTNND2 (delta 2 catenin), RAB34 (a member of the RAS oncogene family), SOX13 (SRY (sex determining region Y)-box 13), ETV4 (ets variant gene 4), DNMT1 (DNA cytosine-5-methyltransferase 1), TLE3 (transducin-like enhancer of split 3), MLL (myeloid/lymphoid or mixed-lineage leukemia), and MLL2, have been associated with tumor malignancy and poor patient outcomes in HCC or other cancers (Figure 1E, underlined). This evidence concerns the gene KMT2A and hepatocellular carcinoma.