To determine the clinical significance of LARP1, the correlation between the clinicopathological features of HCC and LARP1 expression was investigated in a retrospective cohort of 272 HCC cases by IHC, including 16 cases of stage I (5.9%), 195 cases of stage II (71.7%) and 61 cases of stage III (22.4%) , based on the TNM staging. The gene discussed is LARP1; the disease is hepatocellular carcinoma.