PTGS2 and gastric cancer: Based on this clinical phenomena, AGS gastric adenocarcinoma cell line which constitutively expressed both COX-1 and COX-2 and additional COX-2 induced by IL-1β to potentially make it an excellent model for assessing gastrointestinal toxicity of COX-2 inhibitors was an ideal model to evaluate the potential compound for adjuvant therapy in gastric cancer [11].