BRCA1 and breast cancer: More than 3500 mutations have been reported that affect the BRCA1/2 genes, about one-third of which are unclassified variants (UVs) (Breast Cancer Information Core Database (BIC), French UMD-BRCA1/2 mutation database: http://www.umd.be/BRCA2/, http://www.umd.be/BRCA1/) that may induce aberrant splicing.