The RTPCR study performed on the harvested tumor tissues reveals 50.7 ± 19.5% gene silencing (P = 0.031) with PLK1 siRNA delivered by CS-PEG-CP15 chitosan nanoparticles as compared to the control (Figure 5), and PLK1 siRNA (P = 0.539) delivered alone had no effect on the PLK1 gene expression compared with the control. The gene discussed is PLK1; the disease is neoplasm.