The conclusion from all of these studies is that T replacement treatment can be given to those patients who underwent radical prostatectomy for cT1-2, a Gleason score of 7, and serum PSA level of 10 ng/mL PCa and who had negative surgical margins and no lymph node involvement, after achieving a postoperative nadir serum PSA level. Here, KLK3 is linked to posterior cortical atrophy.