Regarding eWAT, these results agree with the fact that CL316243 stimulated PPARα expression and fatty acid β-oxidation (Cpt1b and Acox1) and reduced the expression of Scd1, a critical control point of lipid partitioning, obesity development and diet-induced hepatic insulin resistance (Gutiérrez-Juárez et al., 2006; Jiang et al., 2005). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.