If anti-HBs do not appear during the HBV infection, it results either in HBsAg carrier status, which is associated with detectable HBV deoxyribonucleic acid (DNA) in about 65 % of infected HD patients [3, 4], or in the occurrence of isolated anti-HBc positivity (anti-HBc positive individuals are both HBsAg and anti-HBs negative), which in HD patients may be associated with detectable HBV DNA [5]. The gene discussed is KRT88P; the disease is Huntington disease.