IL12B and kidney disorder: In the best regression models that included gender, age, RRT vintage, kidney diseases, liver enzymes, HBsAg, anti-HCV, history of hepatitis B, and polymorphic variants of IL-12B (P < 0.001 for a significance of each model), there was a positive association of anti-HBs development in response to hepatitis B infection with the AC polymorphic variant of IL-12B (OR 8.0, 95 % CI 2.6–24.9, P < 0.001); negative associations were shown with HBsAg positivity (OR 0.02, 95 % CI 0.003–0.07, P < 0.001) and the CC polymorphic variant of IL-12B (OR 0.1, 95 % CI 0.03–0.06, P = 0.011).