PPARG and cicatricial alopecia: The apparent pro-inflammatory effects of diclofenac seen, for example, in the skin are, therefore, likely to be a consequence of the effects on the Pparg pathway in non-immune cells, and recent research suggests that it is the effect on the inhibition of PPARg in the pilosebaceceous unit itself that underlies primary cicatricial alopecia, rather than a primary effect on the inflammatory response (Karnik et al., 2009).