Moreover, we found that the expression of E-cadherin was significantly increased, while the expression of mesenchymal markers was decreased in HCC GR cells transfected with PDGF-D siRNA (Figure 5B, 5D), suggesting that down-regulation of PDGF-D led to the reversal of EMT to MET phenotype. This evidence concerns the gene PDGFD and hepatocellular carcinoma.