Consistent with these findings, in the current study, we found that HepG2 GR cells and SMMC-7721 GR cells demonstrated altered morphological characteristics of cells similar to EMT with decreased E-cadherin and increased Vimentin, Snail and Slug, suggesting that there is a link between chemo-resistance and EMT in HCC. The gene discussed is SNAI2; the disease is hepatocellular carcinoma.