ERBB2 and breast carcinoma: HER2 was overexpressed in several cancers, such as breast cancers [11], colon [12], bladder [13], ovarian [14], endometrial [15], lung [16], uterine cervix [17], head and neck [18], esophageal [19] etc. HER2 proteins have been shown to form clusters in cell membranes that may play a role in tumorigenesis [20, 21].