While the levels of FASN mRNA remained unaltered (Fig. 5F), KLK5-expressing cells exhibited significantly lower rates of free fatty acid (FFA) biosynthesis (Fig. 4G and H), which may be linked to suppressed malignancy since it is well-established that decreased FFA is associated with reduced aggressiveness of tumor cells [25]. This evidence concerns the gene KLK5 and neoplasm.