As shown in Figure 1D, only infection of sh FBXL5 and, to a minor extent, that of FBXW5, caused an increase in Snail1-HA levels; no stabilization was observed with shRNAs against FBXO3, FBXO5 and FBXO27 and only a modest increase with shRNAs against FBXO4, FBXO24 and FBXO25, suggesting that Snail1 upregulation by depletion of these ubiquitin ligases is indirect. The gene discussed is FBXO4; the disease is infection.