In trauma patients, biomarkers of fibroblast activation (PCPIII), endothelial injury (ANG2), other inflammatory markers (IL-10, TNF) and heart failure (BNP, lower in ARDS) were also useful for differentiating cases from controls whereas in sepsis, biomarkers of lung epithelial injury (SPD, RAGE, CC16) and inflammation (IL6, IL8) predominate. This evidence concerns the gene ANGPT2 and acute respiratory distress syndrome.