IGF1R and cancer: Analysis of HFD-E tumor characteristics showed increased cellular proliferation that was associated with upregulation of genes that promote cellular proliferation such as Bmp7, Ccdn2, Inha, and Igf1r. BMPs are recognized as key regulators during the control of cell fate and cancer development [58], and BMP signaling can downregulate levels of mitotic checkpoint components in human breast cancer cells [59].