In addition, the predominance of Ang-2 over Ang-1 in the ovary, increased Ang-2 follicular fluid levels in PCOS, and the correlation of follicular fluid Ang-2 levels with number of oocytes retrieved suggest a potential role for Ang-2 in the angiogenic dysregulation seen in PCOS women, and their predisposition for OHSS development. Here, ANGPT2 is linked to polycystic ovary syndrome.