Whereas, some chalcones were found to inhibit glutathione and glutathione peroxidase (GPx) in hydrogen peroxide (H2O2) induced toxicity in liver cancer cells HepG2[36], but other chalcones were proved to increase the endogenous cellular enzymes SOD, CAT and GPx in Hydrogen peroxide-oxidative stress in neuroblastoma cells [37]. Here, SOD1 is linked to liver cancer.