Pre-stimulation of NK cells by S100A9 tetramers induced a significant decrease in the percentage of CD3+ T cells replicating the virus (Figure 5B), at day 7 and 10 post-infection, and this decrease was abrogated when NK cells were pre-stimulated with a combination of S100A9 tetramers and CD85j-Fc. The gene discussed is S100A9; the disease is infection.