Mutations of COL4A1 gene have been initially reported in a mouse bearing a heterozygous that results in in-frame deletion of exon 40, this mutation causes abnormal synthesis of the protein and the protein cannot be properly secreted outside the cell, finally leading mouse prone to brain hemorrhage at their birth [21].In addition, Gould DB et al. [22] also observed that with in-frame deletion of exon 40 may predispose adult mouse to vascular fragility and act in concert with birth trauma to cause cerebral hemorrhage. Here, COL4A1 is linked to intracranial hemorrhage.