Research about the relationship between polymorphisms of COL4A1 gene and cardiovascular diseases was first reported by Yamada Y et al. [12], they demonstrated that the A → C (Gln1334His) polymorphism (rs3742207) of COL4A1 is associated with prevalence of MI in Japanese people, with C allele protecting against this condition. Here, COL4A1 is linked to cardiovascular disorder.