EML4 and neoplasm: To address all these knowledge gaps, we conducted a comprehensive investigation of ALK gene in tumor samples from IBC patients using immunohistochemistry (IHC) to evaluate ALK protein expression, fluorescence in situ hybridization (FISH) for EML4-ALK rearrangement, and array comparative genomic hybridization (CGH) and transcriptional profiling to evaluate copy number and mRNA levels of the ALK gene.