ALK and non-small cell lung carcinoma: Treatment with ALK inhibitors in vitro has been reported to lead to cell cycle arrest and apoptosis in anaplastic large-cell lymphoma, NSCLC, and neuroblastoma cells with any of the noted ALK rearrangements (Wan et al. 2006; Christensen et al. 2007; Galkin et al. 2007; McDermott et al. 2008).