Moreover, Listeriaat-Mage-b significantly increased the production of IL-6 in sub populations of the MDSC (with an exception of gMDSC in tumors), probably to protect themselves from immune clearance, but as mentioned above curcumin strongly reduced the IL-6 production in both types of MDSC in blood and primary tumor (Fig. 4C–E). Here, IL6 is linked to neoplasm.