It is possible that the production of IL-6 was not sufficiently reduced in the primary tumors (IL-6 was reduced in the tumor cell lysates by ~65% by Listeriaat-Mage-b and curcumin treatment), and other inhibitory cytokines likes TGFβ, which is highly produced by 4T1 tumor cells 55, may play here a role as well. This evidence concerns the gene IL6 and neoplasm.