CDKN2A and neoplasm: Likewise, when p16INK4a overexpression was analyzed separately for HPVDNA+ and HPVDNA− tumors in the multivariate analyses adjusted for sex, stage, age, and tumor site, there was only a significant correlation to OS in the HPVDNA+ group and not in the HPVDNA− group (multivariate DFS: P = 0.28 and OS: P < 0.0001, respectively) (Table 3A and B).