Therefore, we speculate that the strong antitumor effect showed by L-M-G-G schedule in K7M2 osteosarcoma is principally due to the efficacy of the vascular-targeted L19mTNF-α that induces massive tumor necrosis 11 with release of proinflammatory cytokines and chemokines 38, and tumor antigens that enhance the tumor immunogenicity and stimulate the activation of CD8+ T cells necessary for tumor eradication. The gene discussed is CD8A; the disease is osteosarcoma.