MMP14 (MT1-MMP) is a membrane-type metalloproteinase with collagenase activity and has been implicated to play a role in many biological processes in normal and tumor tissues 8 Although majority of the studies involving MMP14 primarily focus on angiogenesis 9–10 and invasion 11–12, recent studies have also pointed to the involvement of MMP14 in tumor proliferation 13 and remodeling of extracellular matrix and basement membrane 14. The gene discussed is MMP14; the disease is neoplasm.