Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R et al.: Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease - A meta-analysis. Jama-Journal of the American Medical Association 1997, 278: 1349-1356. The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.