Mutations in ankyrin-B are known to lead to altered Ca2+ handling and pathological ECG changes, including QT prolongation, bradycardia, sinus arrhythmia, idiopathic ventricular fibrillation, catecholaminergic polymorphic ventricular tachycardia, and risk of sudden death [75,76]. Here, ANK2 is linked to paroxysmal familial ventricular fibrillation.