In line with this, our group has demonstrated previously that in human colon (HT25) and epidermoid carcinoma (A431) xenograft models, rHuEPOα administration significantly decreased tumoral hypoxia and HIF-1α and vascular endothelial growth factor (VEGF) expressions but had no effect on tumor growth. The gene discussed is HIF1A; the disease is squamous cell carcinoma.