To further testify the correlation between dysregulation of HOTAIR/p21 and the sensitivity of LAD cells to cisplatin, we analyzed the expression of HOTAIR and p21 mRNA or protein in “cisplatin-sensitive” or “cisplatin-insensitive” LAD tissues, and found that the expression of HOTAIR in LAD tissues was negatively correlated with the responses of LAD patients to cisplatin-based chemotherapy. Here, HOTAIR is linked to leukocyte adhesion deficiency.