To better understand the correlation of HOTAIR-p21 dysregulation in LAD tissues and the clinical response to cisplatin-based regimens, qRT-PCR was performed to detect the relative expression level of HOTAIR and p21 mRNA on tumor tissues from 41 eligible patients with advanced LAD treated with cisplatin-based chemotherapy was performed. The gene discussed is HOTAIR; the disease is leukocyte adhesion deficiency.