LCK and neoplasm: Moreover, we revealed that Tyr-342 phosphorylation plays an important role in downregulating the MMP9, SKP2, which is essential for progression into mitosis in cell cycles [29] and suppressed by FOXP3 [15], and VEGF-A expression, which regulates tumor angiogenesis, and is upregulated by LCK [22], and the suppression of the invasive ability is enhanced by LCK.