BCL2 and central nervous system cancer: Interestingly, MCL1 is the most over-expressed protein of the BCL2 family in the majority of malignant gliomas, and neutralization of MCL1 in glioma cells has been reported to induce apoptosis and increase chemotherapy-induced apoptosis [38], suggesting that miR-29a/29b over-expression could be studied as a possible therapy for GBM.