ACSL4 and cancer: Figure 8 (A-C) documents the differential effects of tamoxifen, etoposide and the ACSL inhibitor, triacsin C, on control- and ACSL4-MCF-7 cells. In each case, expression of ACSL4 correlates with increased resistance to the therapeutic regimen, suggesting an overall effect to increase survival in general. These findings are in line with those previously reported suggesting that ACSLs, in general, are cancer survival factors that can inhibit the efficacy of etoposide [32]