Best evaluated with respect to the association with CAD or related intermediate phenotypes in RAGE gene are four common polymorphisms, viz. rs1800625 (T-429C) and rs1800624 (T-374A) in the promoter region, rs2070600 (Gly82Ser) in 3rd exon, and rs184003 (G1704A) in 7th intron. The gene discussed is AGER; the disease is coronary artery disorder.