To investigate the mechanisms underlying the increased DPF3 expression in CLL, we performed ChIPs in granulocytes, total PBMCs, and CLL cell lines to evaluate in vivo binding of STAT5 to the promoter of DPF3. Motif analysis of the human DPF3 promoter revealed two STAT5 consensus motifs (TTCN3GAA) and one non-consensus motif (TTCN3GCA) (Figure S6 in File S1). Here, STAT5A is linked to B-cell chronic lymphocytic leukemia.