To investigate the mechanisms underlying the increased DPF3 expression in CLL, we performed ChIPs in granulocytes, total PBMCs, and CLL cell lines to evaluate in vivo binding of STAT5 to the promoter of DPF3. Motif analysis of the human DPF3 promoter revealed two STAT5 consensus motifs (TTCN3GAA) and one non-consensus motif (TTCN3GCA) (Figure S6 in File S1). This evidence concerns the gene STAT5B and B-cell chronic lymphocytic leukemia.