KIT and Splenomegaly: From a prognostic point of view, increasing sBT (slope ≥0.15) together with the development of hepatomegaly plus splenomegaly, were the only two informative parameters to predict for multilineal involvement of BM cells by the KIT mutation (p = 0.01, and p = 0.009, respectively; Table 4); furthermore, multivariate analysis confirmed that both parameters were independent and that they provide the best combination of factors to predict for multilineal KIT mutation with a 100% specificity (19% false-negative and 0% false-positive results; Table 4).