PNPLA3 and metabolic dysfunction-associated steatotic liver disease: In ALD&NAFLD, homozygosity for the PNPLA3 148M allele was the only negative prognostic factor (hazard ratio (HR) 1.87, 95% c.i. 1.12–2.78), whereas in patients with other liver diseases, age, advanced stage, and type 2 diabetes negatively influenced survival.