In ALD&NAFLD, homozygosity for the PNPLA3 148M allele was the only negative prognostic factor (hazard ratio (HR) 1.87, 95% c.i. 1.12–2.78), whereas in patients with other liver diseases, age, advanced stage, and type 2 diabetes negatively influenced survival. This evidence concerns the gene PNPLA3 and liver disorder.