PNPLA3 and liver disorder: However, when we stratified patients for the two major remaining etiologies (HBV and HCV, results are shown in Table S3), in patients with HBV we observed that PNPLA3 148M alleles were associated with younger age at presentation (p = 0.011; p = 0.032 under a recessive model), shorter time from cirrhosis to diagnosis (p = 0.045, p = 0.20 under a recessive model), and with presentation of HCC at a less advanced stage of liver disease (p = 0.032).