PNPLA3 and hepatocellular carcinoma: In particular, the rs738409 C>G polymorphism, encoding for the functional I148M protein variant in the patatin-like phospholipase domain-containing 3 (PNPLA3, adiponutrin) gene has been associated with the risk of developing HCC [3], [4], [5], [6], [7], [8], [9], [10].