Others [21] described a misfolded SOD1 in the form of granular aggregates in nuclei of glial cells from SALS cases while a iper-oxidized misfolded SOD1 was found aggregated with the anti-apoptotic protein Bcl-2 in the cytoplasm of lymphoblasts from sporadic ALS patients. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.