Furthermore, metabolic inhibition of cultured neonatal cardiomyocytes also induces tyrosine phosphorylation of Cx43 and increased association between c-Src and Cx43 (Chung et al., 2007, 2009), which indicates a role for tyrosine phosphorylation in gap junction uncoupling and/or remodeling during myocardial ischemia. Here, GJA1 is linked to myocardial ischemia.