Moreover, HIF-1α expression was shown to manifest positive correlation with expression of VEGF and with density of microvessels in most of tumours of central nervous system [12], ovarian cancer [13], ductal mammary carcinoma [14], colon adenocarcinoma [15], endometrial adenocarcinoma [16], ductal pancreatic adenocarcinoma [17], small-cell pulmonary carcinoma [18]. This evidence concerns the gene HIF1A and colon adenocarcinoma.