NOS2 and esophageal adenocarcinoma: Using a rat model to study the pathogenesis of Barrett’s esophagus and its progression to esophageal adenocarcinoma, it was shown that iron supplemented rats had significantly higher levels of inflammation, cell proliferation, inducible nitric oxide synthase and nitrotyrosine as well as more tumor in their distal esophagi than did rats that received no iron supplement [144].