Moreover, magnesium deficiency has been associated with increased oxygen-derived free radicals, oxygen peroxide production, decreased antioxidant enzyme expression, and activity [52,53] and higher levels of interleukin 1-β, tumor necrosis factors-α, and IL-6 [54], suggesting again a potential mechanistic link between IGF-1 and inflammation. The gene discussed is IGF1; the disease is nutritional disorder.