Nuclear factor kappa B (NF-κB) is an important regulator of the expression of inflammation and pro-inflammatory response genes such as monocyte chemoattractant protein-1 (MCP-1) and transforming growth factor beta (TGF-β1), which are secreted in the glomerular mesangial cells have become known as the chief mediators of the inflammation process in DN patients [5,6]. This evidence concerns the gene NFKB1 and liver dysplastic nodule.