The expression of MCP-1 that is induced by the non-enzymatic glycosylation of albumin in human mesangial cells in vitro, suggesting that the occurrence of NF-κB-mediated DN is caused by the high-glucose-induced activation of NF-κB occurring through the protein kinase C-NF-κB pathway [7,8]. Here, CCL2 is linked to liver dysplastic nodule.