Small organic molecules have been proposed to interact noncovalently with G-quadruplex through stacking on the ends of the G-tetrad core, groove binding, taking the place of one or more strands in the core, interacting with the backbone (core and loops), or interacting with the loop bases These G-quadruplex elements are often present in biologically important regions of DNA that greatly required by cancer cell to proliferate untimely such as telomere and regulatory regions of oncogenes such as MYC. Here, MYC is linked to cancer.