The therapeutic advantages of such a novel approach to anticancer drugs resides in the evidence that G-quadruplex ligands selectively impair the growth of cancer cells without affecting the viability of normal cells [240,244,249], together with the ability of some of these compounds to exert an antitumor activity in different in vivo models and to induce antiproliferative effects also in ALT cells [61,62,63]. This evidence concerns the gene GPT and cancer.