Whereas both the pro- and anti-tumorigenic effects of TDAG have been reported in different experimental models and cancer cell types [45,48,49,58], the downregulation of TDAG8 in lymphomas, together with the TDAG8-induced inhibition of c-Myc oncogene expression, suggests that TDAG8 may function as a tumor suppressor in lymphoma. This evidence concerns the gene GPR65 and lymphoma.