Cancer types with moderate to high frequencies of non-synonymous mutations in the EGFR pathway (> 50%; Figure 1A) were combined for subsequent analysis: uterine corpus endometrial carcinoma (UCEC), skin cutaneous melanoma (SKCM), thyroid carcinoma (THCA) and colorectal adenocarcinoma (COAD). Here, EGFR is linked to colon adenocarcinoma.