TRAF6 and infection: Both IP6K2 and DIPP-3β interact with TRAF proteins, possibly suggesting some sort of reciprocal regulation in response to infection and inflammation: the activity of IP6K2 is increased in response to binding TRAF2 and so it may be desirable to reduce the activity of DIPP-3β (which binds to TRAF6), although it is not known whether this is the consequence of DIPP-3β binding to TRAF6.