Examination of HeLa cells infected with HSV1 expressing green fluorescent protein (GFP) fused to the glycoprotein gD (gD-GFP) revealed that by 14 h after infection in untreated cells, gD was detected in abundance at the PM and to a lesser extent in the nuclear membrane, while in Rab1 depleted cells it was localized predominantly in an ER pattern and was absent from the PM (Figure 3B). The gene discussed is RAB1A; the disease is infection.