Importantly, the levels of proteins tested for, including the immediate-early protein ICP0, and the late structural proteins VP5 and VP22, were unaffected in either Rab1 or Rab6 knockdowns, confirming that these virus proteins accumulated appropriately in depleted cells and there was no apparent inhibition of early stages of virus infection in these cells (Figure 2A). Here, PROS1 is linked to viral infectious disease.